The Serum Cell-Free microRNA Expression Profile in MCTD, SLE, SSc, and RA Patients
Identifieur interne : 000028 ( an2020/Analysis ); précédent : 000027; suivant : 000029The Serum Cell-Free microRNA Expression Profile in MCTD, SLE, SSc, and RA Patients
Auteurs : Barbara Stypinska [Pologne] ; Anna Wajda [Pologne] ; Ewa Walczuk [Pologne] ; Marzena Olesinska [Pologne] ; Aleksandra Lewandowska [Pologne] ; Marcela Walczyk [Pologne] ; Agnieszka Paradowska-Gorycka [Pologne]Source :
- Journal of Clinical Medicine [ 2077-0383 ] ; 2020.
Abstract
Mixed connective tissue disease (MCTD) is a rare disorder characterized by symptoms that overlap two or more Autoimmune Connective Tissue Diseases (ACTDs). The aim of this study was to determine whether miRNAs participating in the TLRs signaling pathway could serve as biomarkers differentiating MCTD or other ACTD entities from a healthy control group and between groups of patients. Although the selected miRNA expression level was not significantly different between MCTD and control, we observed that miR-126 distinguishes MCTD patients from all other ACTD groups. The expression level of miRNAs was significantly higher in the serum of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients compared to controls. The miR-145 and -181a levels distinguished RA from other ACDT patients. miR-155 was specific for SLE patients. MiR-132, miR-143, and miR-29a distinguished RA and SLE patients from the systemic sclerosis (SSc) group. Additionally, some clinical parameters were significantly related to the miRNA expression profile in the SLE group. SLE and RA are characterized by a specific serum expression profile of the microRNAs associated with the Toll-like receptors (TLRs) signaling pathway. The analysis showed that their level distinguishes these groups from the control and from other ACTD patients. The present study did not reveal a good biomarker for MCTD patients.
Url:
DOI: 10.3390/jcm9010161
PubMed: 31936082
PubMed Central: 7020053
Affiliations:
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Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Wajda, Anna" sort="Wajda, Anna" uniqKey="Wajda A" first="Anna" last="Wajda">Anna Wajda</name><affiliation wicri:level="1"><nlm:aff id="af1-jcm-09-00161">Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Walczuk, Ewa" sort="Walczuk, Ewa" uniqKey="Walczuk E" first="Ewa" last="Walczuk">Ewa Walczuk</name><affiliation wicri:level="1"><nlm:aff id="af1-jcm-09-00161">Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Olesinska, Marzena" sort="Olesinska, Marzena" uniqKey="Olesinska M" first="Marzena" last="Olesinska">Marzena Olesinska</name><affiliation wicri:level="1"><nlm:aff id="af2-jcm-09-00161">Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Lewandowska, Aleksandra" sort="Lewandowska, Aleksandra" uniqKey="Lewandowska A" first="Aleksandra" last="Lewandowska">Aleksandra Lewandowska</name><affiliation wicri:level="1"><nlm:aff id="af2-jcm-09-00161">Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Walczyk, Marcela" sort="Walczyk, Marcela" uniqKey="Walczyk M" first="Marcela" last="Walczyk">Marcela Walczyk</name><affiliation wicri:level="1"><nlm:aff id="af2-jcm-09-00161">Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Paradowska Gorycka, Agnieszka" sort="Paradowska Gorycka, Agnieszka" uniqKey="Paradowska Gorycka A" first="Agnieszka" last="Paradowska-Gorycka">Agnieszka Paradowska-Gorycka</name><affiliation wicri:level="1"><nlm:aff id="af1-jcm-09-00161">Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw</wicri:regionArea><wicri:noRegion>02-637 Warsaw</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical Medicine</title><idno type="eISSN">2077-0383</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mixed connective tissue disease (MCTD) is a rare disorder characterized by symptoms that overlap two or more Autoimmune Connective Tissue Diseases (ACTDs). The aim of this study was to determine whether miRNAs participating in the TLRs signaling pathway could serve as biomarkers differentiating MCTD or other ACTD entities from a healthy control group and between groups of patients. Although the selected miRNA expression level was not significantly different between MCTD and control, we observed that miR-126 distinguishes MCTD patients from all other ACTD groups. The expression level of miRNAs was significantly higher in the serum of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients compared to controls. The miR-145 and -181a levels distinguished RA from other ACDT patients. miR-155 was specific for SLE patients. MiR-132, miR-143, and miR-29a distinguished RA and SLE patients from the systemic sclerosis (SSc) group. Additionally, some clinical parameters were significantly related to the miRNA expression profile in the SLE group. SLE and RA are characterized by a specific serum expression profile of the microRNAs associated with the Toll-like receptors (TLRs) signaling pathway. The analysis showed that their level distinguishes these groups from the control and from other ACTD patients. The present study did not reveal a good biomarker for MCTD patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Didier, K" uniqKey="Didier K">K. Didier</name></author><author><name sortKey="Bolko, L" uniqKey="Bolko L">L. Bolko</name></author><author><name sortKey="Giusti, D" uniqKey="Giusti D">D. Giusti</name></author><author><name sortKey="Toquet, S" uniqKey="Toquet S">S. Toquet</name></author><author><name sortKey="Robbins, A" uniqKey="Robbins A">A. Robbins</name></author><author><name sortKey="Antonicelli, F" uniqKey="Antonicelli F">F. Antonicelli</name></author><author><name sortKey="Servettaz, A" uniqKey="Servettaz A">A. 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Thacker</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Stypinska, Barbara" sort="Stypinska, Barbara" uniqKey="Stypinska B" first="Barbara" last="Stypinska">Barbara Stypinska</name></noRegion><name sortKey="Lewandowska, Aleksandra" sort="Lewandowska, Aleksandra" uniqKey="Lewandowska A" first="Aleksandra" last="Lewandowska">Aleksandra Lewandowska</name><name sortKey="Olesinska, Marzena" sort="Olesinska, Marzena" uniqKey="Olesinska M" first="Marzena" last="Olesinska">Marzena Olesinska</name><name sortKey="Paradowska Gorycka, Agnieszka" sort="Paradowska Gorycka, Agnieszka" uniqKey="Paradowska Gorycka A" first="Agnieszka" last="Paradowska-Gorycka">Agnieszka Paradowska-Gorycka</name><name sortKey="Wajda, Anna" sort="Wajda, Anna" uniqKey="Wajda A" first="Anna" last="Wajda">Anna Wajda</name><name sortKey="Walczuk, Ewa" sort="Walczuk, Ewa" uniqKey="Walczuk E" first="Ewa" last="Walczuk">Ewa Walczuk</name><name sortKey="Walczyk, Marcela" sort="Walczyk, Marcela" uniqKey="Walczyk M" first="Marcela" last="Walczyk">Marcela Walczyk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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